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During Low Vision Awareness Month: Learn More About Helpful Non-Optical Devices for Low Vision

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As we age, our eyes change too. In most cases, regular eyeglasses or contact lenses can correct many of these vision changes.

However, if your eye doctor tells you that your vision cannot be fully corrected with ordinary prescription glasses, medication, or surgery and you still have some usable vision, you have what is called "low vision."

What Is Low Vision?

Having low vision means that even with regular glasses, contact lenses, medication, or surgery, you may find it difficult to perform everyday tasks, such as reading your mail, shopping, preparing meals, and signing your name.

One way to address low vision is through the use of low vision optical devices, such as magnifiers and magnifying reading glasses and small telescopes, and electronic magnifiers and magnifying systems, including electronic desktop and portable digital magnifiers. All of these devices should be prescribed by an ophthalmologist or optometrist who specializes in low vision.

But there is yet another category of low vision devices, called non-optical devices, that can also be helpful for people who have low vision.

What Are Low Vision Non-Optical Devices?

Low vision non-optical devices can include a number of adaptations, such as reading stands, supplemental lighting, absorptive sunglasses, typoscopes, and tactile locator dots (all explained below). They are often recommended as part of a low vision examination, and can be used in combination with magnifiers and other low vision optical devices that can help with reading and a variety of tasks.

Flexible-Arm Task Lamps

Proper lighting is critical for good vision. A person age 65 or older may need much more light to read than does a 10-year-old – by some estimates, between four and fifteen times more light. And importantly, a person with low vision may need three times as much light to read as a person their age who does not have a vision loss. Therefore, flexible-arm desk or floor task lamps are perhaps the most helpful and important non-optical devices for many people.

flexible-arm task lamp

A flexible-arm desk lamp

Some advantages of flexible-arm task lamps are:

  • They are obtained easily at a variety of stores, catalogs, or online.
  • They can be relatively inexpensive.
  • They can be adjusted to a variety of settings and tasks.

Some disadvantages of flexible-arm task lamps are:

  • Some lamps may become very hot, so be careful not to touch them.
  • It's important to position the light so that it is not shining directly into your eyes and creating glare.
reading with a flexible-arm desk lamp

Reading a label with
flexible-arm desk lamp

There are many types of lamps: incandescent, halogen, fluorescent, LED, and full spectrum. Try different lamps to see what you prefer. Try to choose one that is a low "Kelvin" rating – under 5,000 Kelvin (K) – so that it does not emit ultraviolet or blue light. You can read more about the different types of light at Lighting for Reading at

Perhaps even more important than the type of light is the position of the light—particularly the distance from the lamp to the task you are doing or to your eye. Bring the lamp closer to help maximize the light delivered to the task and your eye.

For more information about helpful lighting for reading, you can view Positioning a Light Source and Minimizing Glare in the VisionAware Better Lighting for Better Sight video series.

Reading Stands

Reading stands can help with both reading and writing, by allowing you to position your reading and writing materials more effectively. Using a reading stand when you read or write with a flexible-arm task lamp and your stand magnifier or other optical devices will increase your success dramatically.

a reading stand

One type of reading stand

Some advantages of reading stands are:

  • They bring reading and writing materials closer to your eye, thus helping to achieve "relative distance" magnification: enlarging letters and words by bringing them closer.
  • They help you see a wider field of view, or more lines and text at a time, because the image is closer to your eye.
  • They allow better illumination, because you are not bending over to read, which can block out the light.
  • They provide better posture and ergonomics, which leads to less fatigue and strain on your neck and back.

Absorptive Sunglasses

Glare is a major problem and concern for many persons with low vision. Absorptive sunglasses help filter out bothersome glare and harmful light rays. Most sunglasses now block out ultraviolet light. However, to block out "blue" light, which causes concern for macular degeneration and other eye conditions, sunglasses need to have some amount of yellow in them.

The colors of sunglasses that contain some yellow and block out blue light are: amber, orange, amber/orange combination, plum, and yellow. Grey and green-grey colored sunglasses do not block out any blue light. Grey and green-grey sunglasses also do not provide as good contrast as do amber, orange, plum, and yellow.

absorptive lenses in amber fit over regular eyeglasses

Absorptive sunglasses
in amber fit over
regular eyeglasses

Some advantages of absorptive sunglasses are:

  • They can reduce bothersome glare, enhance or clarify vision in the sunlight, ease eye fatigue, and protect the eyes from injuries, such as walking into a low-hanging branch.
  • They block out harmful light rays. Most block out ultraviolet (UV) light, while amber, orange, plum, and yellow-colored sunglasses also block out blue light.
  • Amber, orange, plum, and yellow-colored sunglasses also help enhance or increase contrast.
  • Yellow-colored sunglasses are helpful for use indoors (reading, writing, doing handicrafts, using a computer) to reduce glare and enhance contrast.
  • They are generally inexpensive and easy to obtain.
  • They can be fitted over regular glasses, and they are available in clip-on or insert styles.
  • Please note: Clip-ons and inserts are usually not as effective as fit-over or wrap-around styles, since they do not block light from the top and sides.
  • It is recommended that you try on a range of colors and styles during the low vision examination to determine which color or colors work best for you.


A typoscope is an inexpensive piece of durable black plastic with a cutout opening that can help you focus on the line you are reading.

typoscope in place on paper

A typoscope in place
on the reading page

Some advantages of typoscopes are:

  • They can help you follow, or track, along the reading line; keep your place on the line; and track back to the beginning of the next line.
  • A person who has had a stroke and resultant hemianopia (loss of half of the visual field) can benefit from a typoscope when reading.
  • They can help draw your attention to where to look on the page.
  • They provide excellent contrast with the reading page.

A typoscope can also be used as a signature guide, especially for people with longer names. For more information about typoscopes, handwriting, and other types of signature guides, see Signing Your Name and Handwriting If You are Blind or Have Low Vision at You can find typoscopes, along with a variety of rigid and flexible signature guides in Sources of Products for Independent Living at

Locator or Bump Dots

Locator or bump dots are black, red, orange, and yellow raised foam or plastic dots with adhesive backing that are used to mark appliances, dials, computers, and keyboards.

orange touch dots

A sheet of orange
locator dots

Some advantages of locator or bump dots are:

  • They are highly visible for people with low vision.
  • They are also highly tactile.
  • Because they come in various sizes and shapes (usually round or square), touch dots can help locate a specific setting on a dial, control, or device.
  • They can be used on ovens and stoves, washer and dryer dials, thermostats, microwaves, phones, calculators, and countless other applications.

For more information about additional labeling and marking techniques, see Labeling and Marking at You can find locator dots, along with a variety of other helpful marking materials, at Find Labeling Products and Sources of Products for Independent Living on this website.

Colored Acetate Sheets

a yellow acetate sheet placed on a book page

A yellow acetate sheet
on a catalog page

  • When placed on the page, a translucent acetate sheet—especially yellow—can enhance the contrast between the print and background, making words and letters appear darker and easier to read.
  • A yellow acetate sheet can make newsprint easier to read by increasing the contrast and making the print "stand out" from the background.
  • The yellow acetate sheet fits directly over a letter-sized sheet of paper and can also reduce glare on the reading page.
  • They are generally inexpensive and are readily available at stationery, office supply, and "big box" stores.

Related Information

Environmental assessment and modification
Helpful Products
Low Vision
Macular Degeneration

Our Readers Want to Know: What Does It Mean When My Eye Doctor Tells Me I Have "Low Vision"?

logo for AMD/Low Vision Awareness Month

Editor's note: One of the many benefits associated with an online information center and website, such as VisionAware, is the ability to track readers' search terms [i.e., information readers are seeking as they search online].

Of particular concern to many readers are issues related to the diagnosis and treatment of low vision, as evidenced by the following searches:

  • I've been told I have low vision, but what does this mean?
  • How is low vision different from blindness?
  • Is there a cure for low vision?

An Answer from VisionAware: What "Low Vision" Means

As we age, our eyes change too. In most cases, regular eyeglasses or contact lenses can correct many of these vision changes. However, if your eye doctor tells you that your vision cannot be fully corrected with ordinary prescription glasses, medication, or surgery and you still have some usable vision, you have what is called "low vision."

Having low vision means that even with regular glasses, contact lenses, medication, or surgery, you may find it difficult to perform everyday tasks, such as reading your mail, shopping, preparing meals, and signing your name.

Signs and Symptoms of Low Vision

There are many signs and symptoms that can indicate low vision. For example, even with your regular eye glasses, do you have difficulty:

What Causes Low Vision?

Among older persons, low vision can result from specific eye conditions, such as macular degeneration, glaucoma, and diabetic retinopathy; from a stroke; or from a range of other eye conditions. Low vision can affect your ability to see people's faces, watch television, read, drive, and use a computer.

What You Should Know about Low Vision

Having "low vision" is not the same as being "blind." For example, your doctor may tell you that you have a blind or blank spot in the center of your vision that limits your ability to read or see people's faces; nevertheless, you can still get around using your side (or peripheral) vision:

Simulation of the effects of macular degeneration, with central visual field loss

A simulation of central visual field loss from macular degeneration
Source: Henry Ford Center for Vision Rehabilitation and Research

Or you may have problems seeing well with your peripheral (or side) vision, but still see clearly enough to read the newspaper using your central vision:

A living room viewed through a constricted visual field

A living room viewed through a constricted visual field.
Source: Making Life More Livable. Used with permission.

There is Help for Low Vision

The important thing is to know that help is available for you. For example, eye doctors who are low vision specialists can provide you with a low vision exam as a first step in determining how you can use your remaining vision. Often, a low vision specialist can give you recommendations about low vision optical devices, non-optical devices, electronic magnifiers, and vision rehabilitation services that can help you maximize your remaining vision and learn new ways of doing everyday tasks.

Some examples of helpful devices that a low vision specialist can discuss with you include:

Reading with an illuminated stand magnifier

Reading with a lighted
stand magnifier

Low Vision Services

Low vision services can include any or all of the following:

What Are Low Vision Devices?

a hand-held stand magnifier

Stand magnifier with a handle

Low vision devices can help you make the most of your vision so that you can perform everyday tasks more easily and with less frustration.

Some devices, such as optical and non-optical aids, offer very simple and relatively inexpensive solutions. Other devices, such as electronic and digital magnifiers, may be slightly more complex and costly.

However, both optical devices and electronic or digital devices require training to use them efficiently and effectively. Training is always one of the main keys to success with the use of low vision devices.

There are several different categories of low vision devices: optical devices, non-optical devices, and electronic magnifiers and magnifying systems. Low vision devices are task-specific, designed for close-up visual tasks or distance viewing. You may require several different devices to accomplish different tasks, depending upon your eye condition and your everyday living needs.

Low Vision Optical Devices

Low vision optical devices include a variety of helpful visual aids, including stand and hand-held magnifiers, strong magnifying reading glasses, loupes, and small telescopes. Because these devices can provide greatly increased magnification powers and prescription strengths, along with higher-quality optics (i.e., the way the lens bends or refracts light), they are different from regular glasses and magnifiers that you can buy in a local store or online. Most often they require training to help you use them effectively.

Low Vision Non-Optical Devices

Low vision non-optical devices can include adaptations such as reading stands, supplemental lighting, absorptive (or glare control) sunglasses, typoscopes, and tactile locator dots. They can be used in combination with low vision optical devices and can help with reading, organizing, labeling, and a variety of everyday tasks.

Electronic Magnifying Systems

Electronic magnifying systems come in many different varieties and sizes, depending upon the task or activity you want, or need, to do. Some have a camera system that displays a magnified image on a monitor, which can be helpful for reading mail, books, and magazines, while others are hand-held, portable, and can be taken to the supermarket to read labels and coupons, or to restaurants for reading menus.

How Can I Obtain a Low Vision Device?

They are often recommended as part of a low vision examination. A low vision exam by a low vision specialist — an ophthalmologist or optometrist with credentials or specialization in low vision testing, diagnosis, and treatment — is the best way to decide what type of device or devices are best for you, your eye condition, and your everyday living needs. At your low vision evaluation, you will have the opportunity to try a variety of devices in a variety of settings and learn first-hand how they can work for you.

For more information about low vision services and providers, see Meet Joseph Fontenot, MD, CVLT: Be Informed and Proactive About Low Vision Services, Protect Yourself, and Always "Buyer Beware" on the VisionAware blog.

How Can I Locate a Low Vision Specialist?

You can find a listing of low vision specialists in the Low Vision Services category in the AFB Directory of Services. In addition to the low vision providers in the Directory listings, you can find additional providers through the following directories:

Related Information

Assistive Technology
Diabetes and diabetic retinopathy
Environmental assessment and modification
Low Vision
Macular Degeneration
Retinitis Pigmentosa
Stroke or Brain Trauma

New Macular Degeneration Research: Will My AMD Affect Both Eyes? If So, How Soon Will That Happen?

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Two questions asked most frequently by readers about age-related macular degeneration (AMD) involve (a) individual risk for the disorder and (b) the likelihood of eventual involvement of both eyes. In response, several recent studies have attempted to address these critically important questions:

Now, an international group of researchers from the three-continent AMD Consortium have combined data from the Blue Mountains Eye Study, the Beaver Dam Eye Study, and the Rotterdam Study (all explained below) and concluded that "one in four to one in five unilateral [i.e., occurring in one eye] any stage [i.e., early through late] of AMD cases, and up to one in two unilateral late AMD cases, progressed to bilateral [i.e., both eyes] in 5 years. Known AMD risk factors, including smoking, are significantly associated with the progression to bilateral involvement."

From the British Journal of Ophthalmology

This new macular degeneration research, titled Five-year progression of unilateral age-related macular degeneration to bilateral involvement: the Three Continent AMD Consortium report, has been published "online first" in the January 2017 edition of the British Journal of Ophthalmology (BJO). BJO is an international peer-reviewed journal for ophthalmologists and visual science specialists that publishes clinical investigations, clinical observations, and clinically relevant laboratory investigations related to ophthalmology.

The authors are members of the AMD Consortium (with all authors listed online) and represent the following countries and institutions: University of Sydney; University of Newcastle; John Hunter Hospital and Hunter Medical Research Institute, Australia; Erasmus Medical Center, Rotterdam; Royal Netherlands Academy of Arts and Sciences, Leiden; Netherlands Genomics Initiative, The Hague; Radboud University Nijmegen Medical Center, The Netherlands; Case Western Reserve University, Cleveland, Ohio; University of Wisconsin School of Medicine and Public Health, United States.

More about Age-Related Macular Degeneration

NEI image of how someone with macular degeneration sees: overall blurriness with a blind spot in the center

Looking at the world with AMD

Age-related macular degeneration (AMD) is a gradual, progressive, painless deterioration of the macula, the small sensitive area in the center of the retina that provides clear central vision. Damage to the macula impairs the central (or "detail") vision that helps with essential everyday activities, such as reading and writing, preparing meals, watching television, and personal self-care.

AMD is the leading cause of vision loss for people aged 60 and older in the United States. According to the American Academy of Ophthalmology, 10-15 million individuals have AMD and about 10% of people who are affected have the "wet" type of AMD.

Wet (Neovascular) Macular Degeneration

In wet, or exudative, macular degeneration (AMD), the choroid (a part of the eye containing blood vessels that nourish the retina) begins to sprout abnormal new blood vessels that develop into a cluster under the macula, called choroidal neovascularization (neo = new; vascular = blood vessels).

Because these new blood vessels are abnormal, they tend to break, bleed, and leak fluid under the macula, causing it to lift up and pull away from its base. This damages the fragile photoreceptor cells, which sense and receive light, resulting in a rapid and severe loss of central vision.

Dry Macular Degeneration

Photograph of a retina with drusen

A retina with dry AMD and drusen

The dry (also called atrophic) type of AMD affects approximately 80-90% of individuals with AMD. Its cause is unknown, it tends to progress more slowly than the wet type, and there is not – as of yet – an approved treatment or cure.

"Atrophy" refers to the degeneration of cells in a portion of the body; in this case, the cell degeneration occurs in the retina.

In dry age-related macular degeneration, small white or yellowish deposits, called drusen, form on the retina, in the macula, causing it to deteriorate or degenerate over time.

Drusen are the hallmark of dry AMD. These small yellow deposits beneath the retina are a buildup of waste materials, composed of cholesterol, protein, and fats. Typically, when drusen first form, they do not cause vision loss. However, they are a risk factor for progressing to vision loss.

Risk Factors for Macular Degeneration

The primary risk factors for AMD include the following:

  1. Smoking: Current smokers have a 2-3 times higher risk for developing AMD than do people who never smoked. It's best to avoid second-hand smoke as well.
  2. Sunlight: Ultraviolet (UV) light is not visible to the human eye, but can damage the lens and retina. Blue light waves that make the sky, or any object, appear blue, are visible to the human eye and can also damage the lens and retina. Avoid UV light and blue/violet light as much as possible by wearing sunglasses with an amber, brown, or orange tint that blocks both blue and UV light.
  3. Uncontrolled hypertension: The National Eye Institute (NEI) reports that persons with hypertension were 1.5 times more likely to develop wet macular degeneration than persons without hypertension. It's important to keep your blood pressure controlled within normal limits.
  4. A diet high in packaged, processed food and low in fresh vegetables: NEI suggests that eating antioxidant-rich foods, such as fresh fruits and dark green leafy vegetables (kale, collard greens, and spinach) may delay the onset or reduce the severity of AMD. Eating at least one serving of fatty fish (salmon, tuna, or trout) per week may also delay the onset or reduce the severity of AMD.
  5. Race: According to NEI, Whites/Caucasians are more likely to have AMD than people of African descent.
  6. Family history: NEI reports that individuals with a parent or sibling with AMD have a 3-4 times higher risk of developing AMD.

You can read more about the full range of AMD risk factors at Risk Factors for Age-Related Macular Degeneration on the VisionAware website.

What is the Blue Mountains Eye Study?

The longitudinal Blue Mountains Eye Study (BMES), named after the Australian mountain range, is the first large population-based assessment of visual impairment and common eye diseases of a representative sample of older Australians. A longitudinal study follows, and gathers information about, the same individuals or group of people over an extended period of time – often many decades.

The ongoing BMES began in 1992-1993, with the recruitment of 3,654 people aged 50 and older. Follow-up exams were conducted in 1997-1999 (5-year), 2002 (10-year) and 2007-2009 (15-year). You can read more about the BMES at Research Data Australia.

What is the Beaver Dam Eye Study?

The longitudinal Beaver Dam Eye Study is funded by the National Eye Institute. The purpose of the Study is to collect information on the prevalence and incidence of age-related cataract, macular degeneration, and diabetic retinopathy. The study was designed to discover, or detect, causes of these conditions.

The study was funded initially in 1987. A private census conducted in the city and township of Beaver Dam, Wisconsin found that there were approximately 6,000 people aged 43 through 84 years. Approximately 5,000 of them participated in the baseline examination between 1988 and 1990.

Five-, 10-, 15-, and 20-year follow-up examinations have taken place and 3,700; 2,800; 2,100; 2,000; and 1,900 people participated in each of the respective examination phases. Thus far, there have been more than 300 publications describing the prevalence and incidence of visual loss, age-related macular degeneration, cataract, and associated risk factors as a result of this study. You can read more about the study at the Beaver Dam Eye Study website.

What is the Rotterdam Study?

The Rotterdam Elderly Study is a longitudinal study in the Ommoord district in Rotterdam, the Netherlands. Following the pilot study in 1989, recruitment began in January 1990. The main objectives of the Rotterdam Study are to investigate the risk factors of cardiovascular, neurological, ophthalmological, and endocrine diseases in older persons. The study has recruited approximately 15,000 subjects aged 45 years or older.

Participants were interviewed at home and received an extensive set of examinations, repeated every 3-4 years. They were followed for the most common diseases in older persons, including coronary heart disease, heart failure, and stroke; Parkinson's disease; Alzheimer's disease and other dementias; depression and anxiety disorders; macular degeneration; glaucoma; diabetes; and osteoporosis. You can read more about the study at the University Medical Center Rotterdam website.

What the Macular Degeneration Progression Study Found

Excerpted from the study abstract:

Purpose: To assess the 5-year progression from unilateral [i.e., in one eye] to bilateral [i.e., in both eyes] age-related macular degeneration (AMD) and associated risk factors.

Design: Pooled data analyses of three prospective population-based cohorts, the Blue Mountains Eye Study, Beaver Dam Eye Study and Rotterdam Study.

Methods: Retinal photography and interview with comprehensive questionnaires were conducted at each visit of three studies. AMD was assessed following the modified Wisconsin AMD grading protocol. Progression to bilateral any (early and late) or late AMD was assessed among participants with unilateral involvement only.

Results: In any 5-year duration, 19–28% of unilateral any [i.e., early through late] AMD cases became bilateral and 27–68% of unilateral late AMD became bilateral. Factors associated with the progression to bilateral involvement of any AMD were age, carrying risk forms of the complement factor H (CFH) and age-related maculopathy susceptibility 2 (ARMS2) genes, smoking, and the presence of large drusen area or retinal pigmentary abnormalities in the first eye.

[Editor's note: The CFH gene makes a protein called complement factor H (CFH), which regulates a part of the body's immune response known as the complement system. It destroys bacteria and viruses, triggers an inflammatory response, and removes debris from cells and tissues. CFH protects healthy cells by preventing the complement system from being activated when it is not needed. (Source: Genetics Home Reference.)]

[The ARMS2 gene provides instructions for making a protein whose function is unknown. Studies suggest that the ARMS2 protein is found primarily in the placenta and in the retina. However, it is unclear what role, if any, the protein plays in early development or normal vision. (Source: Genetics Home Reference.)]

Conclusion: One in four to one in five unilateral any [i.e., early through late] AMD cases, and up to one in two unilateral late AMD cases, progressed to bilateral in 5 years. Known AMD risk factors, including smoking, are significantly associated with the progression to bilateral involvement.

Additional Information About Macular Degeneration

Diabetes and diabetic retinopathy
In the News
Low Vision
Macular Degeneration
Medical Updates

New Glaucoma Research: Will Patients and Family Members Pay for a Glaucoma-Specific App? Not Likely, Results Say

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New – and highly relevant – research from the Wills Eye Glaucoma Research Center, in collaboration with Drexel University, sought to "evaluate the interest of glaucoma patients and their caregivers in a smartphone-based and tablet-based glaucoma application" (app) that contained a range of features (explained below) designed to (a) increase patients' level of knowledge about glaucoma and (b) improve their adherence to medication and follow-up appointment recommendations.

Their research results, which are applicable to doctors, patients, family members, rehabilitation professionals, and app developers, indicate that participants were more likely to download the App if it was free of charge, compared with a version that cost $3.00.

From the Journal of Glaucoma

This new glaucoma app research, titled The Wills Eye Glaucoma App: Interest of Patients and Their Caregivers in a Smartphone-based and Tablet-based Glaucoma Application has been published in the Journal of Glaucoma, the official journal of the American Glaucoma Society. The purpose of the Journal is to provide "a stimulating forum for discussion of clinical, scientific, and socioeconomic issues of greatest concern to clinicians who care for glaucoma patients."

The authors are Michael Waisbourd, MD; Hermandeep Dhami, BSc; Chen Zhou, BSc; Michael Hsieh, BSc; Pramod Abichandani, PhD; Michael J. Pro, MD; Marlene R. Moster, MD; L. Jay Katz, MD; Lisa A. Hark, PhD, RD; and Jonathan S. Myers, MD, from the Glaucoma Research Center, Wills Eye Hospital, and the Drexel University iSchool and College of Engineering, Philadelphia, PA.

About the Wills Eye Hospital Glaucoma App Research

Excerpted from Wills Eye Hospital study details why they built a glaucoma app and patient price sensitivity to medical apps, via iMedicalApps:

Wills Eye Hospital has a [new] glaucoma app for patients called Glaucoma from Wills Eye. They built their glaucoma app over a two-year period, in conjunction with Drexel University's iSchool and College of Engineering. Before releasing the glaucoma app, they did an internal study to see what key features patients would want.

Fifty participants were in the study and they were asked questions on key features they would want in the app. Some key findings from the study were the respondents' answers when it came to mobile technology. Almost 70 percent of patients already had a smartphone or tablet. Nearly half the patients used their smartphones at some point to look up health information.

Out of all the conclusions, the price sensitivity for downloading a health app was the most interesting. While more than 70% of the patients were interested in downloading the Wills Eye Glaucoma app, only 25% of the patients would actually download the app if it was priced at just $3.00. I call this the "Angry Birds" effect. The gaming section is filled with apps that are free or just $0.99. They can afford to do this since there are a significant number of individuals available to download these apps.

For medical specialty apps to succeed financially (be able to at least pay for development costs), they need to charge [a much higher price], since the number of individuals that have the potential to actually use the app is significantly smaller. Unfortunately — even though patients find these types of medical apps useful — the barrier of price, which is similar to a cup of coffee at Starbucks, prevents this from happening.

What Is Glaucoma?

Glaucoma is a group of eye diseases that can lead to blindness by damaging the optic nerve, which transmits information from the eye to the brain, where it is processed and interpreted. The eye continuously produces a fluid, called the aqueous, that must drain from the eye to maintain healthy eye pressure. Glaucoma is particularly dangerous to your vision because there are usually no noticeable initial symptoms or early warning signs.

The Different Types of Glaucoma

Primary Open Angle Glaucoma

The most common type of glaucoma is Primary Open Angle Glaucoma (POAG). In POAG, the eye's drainage canals become blocked, and the fluid accumulation causes pressure to build within the eye. This pressure can cause damage to the optic nerve, which transmits information from the eye to the brain.

Vision loss is with this type of glaucoma is usually gradual, and often there are no early warning signs. There is a strong genetic predisposition for this type of glaucoma.

Angle Closure Glaucoma

Angle Closure Glaucoma is much less common than POAG in the United States. In this type of glaucoma, the aqueous cannot drain properly because the entrance to the drainage canal is either too narrow or is closed completely. In this case, eye pressure can rise very quickly and can be triggered by pupil dilation.

Symptoms can include sudden eye pain, nausea, headaches, and blurred vision. If you experience these symptoms, you should seek immediate medical treatment.

Normal Tension Glaucoma

In this type of glaucoma, also called low-pressure glaucoma, there is damage to the optic nerve, even though the eye pressure is not elevated excessively. A family history of any type of glaucoma, cardiovascular disease, and Japanese ancestry are a few of the risk factors for this type of glaucoma.

This type of glaucoma is treated much like POAG, but the eye pressure needs to be kept even lower to prevent progression of vision loss.

Secondary Glaucomas

Secondary glaucomas are those that develop as secondary to, or as complications of, other conditions, including eye trauma, cataracts, diabetes, eye surgery, or tumors.

Series of four photos demonstrating typical progression of vision loss due to glaucoma. Source: National Eye Institute

The typical progression of vision loss from glaucoma
Source: National Eye Institute

Detecting Glaucoma

National Glaucoma Awareness Month provides an excellent opportunity to learn more about glaucoma, a leading cause of vision loss that affects more than 3 million people in the United States. Glaucoma often is called "the sneak thief of sight" for good reason: Many people are unaware that glaucoma has few symptoms or warning signs in its early stages. Early treatment for glaucoma can usually (but not always) slow the progression of the disease. However, as of yet, there is no cure for glaucoma.

Because glaucoma has no obvious initial symptoms, a comprehensive dilated eye exam is critical to detect early glaucoma changes. People who are over 40 should have a dilated eye examination from an ophthalmologist or optometrist at least every two years. African Americans; people who are over 35 and have a family history of glaucoma; and everyone age 60 or older should schedule a comprehensive eye examination every year.

You can learn more about glaucoma detection and treatment at How Can I Detect Glaucoma if There Are No Initial Symptoms?, What Are the Different Treatments for Glaucoma?, and Tips for Taking Glaucoma (and Other) Eye Drops at VisionAware.

More about the Wills Eye Hospital Glaucoma App

screen shot of the Wills Eye glaucoma app

Screen shot of the app

Excerpted (with screen shot) from the free Wills Eye Hospital Glaucoma App, available at the iTunes Store:

The free Wills Eye Hospital Glaucoma App was designed to educate patients and their caregivers about glaucoma and help them manage their eye disease by using an automated eye-drop reminder feature and a calendar for tracking eye exam appointments. The main features of the App include:

  • Educational videos about glaucoma, how to use eye drops, benefits of glaucoma laser treatment, and surgery
  • Tutorial on how to take a visual field examination
  • Eye-drop reminder feature
  • Appointment reminder feature
  • Storage of medical information
  • Tracking of eye pressure results

Compatibility: Requires iOS 8.0 or later. Compatible with iPhone, iPad, and iPod touch.

More about the Study from the Journal of Glaucoma

Excerpted from the study abstract:

Purpose: To evaluate the interest of glaucoma patients and their caregivers in a smartphone-based and tablet-based glaucoma application (App), developed by the Wills Eye Glaucoma Research Center in collaboration with Drexel University.

Materials and Methods: Cross-sectional survey of patients with glaucoma and their caregivers. Main outcome measures are answers to survey questions regarding how receptive participants are to using the Glaucoma App.

Results: Fifty subjects completed the survey. The mean age was 59.5 years. A total of 88.6% of the participants lived in a household with access to a smartphone or tablet. The majority (72.3%) of participants would consider downloading the Glaucoma App, and younger participants (less than 65 years) were more likely to do so compared with their older (more than, or equal to, 65 years) counterparts.

Participants were more likely to download the App if it was free of charge, compared with a version that costs $3. Although only about one third (37.8%) of participants used eye drop reminders, nearly 3 of 4 (72.9%) participants were receptive to using the automated reminder feature of the Glaucoma App.

Conclusions: Glaucoma patients and their caregivers were very interested in using a Glaucoma App; however, many were not willing to spend $3 for an App they seem to value. The free Wills Eye Glaucoma App currently available on the Apple store, includes educational videos, eye drop and appointment reminders, medical and ocular data storage, visual field tutorial, and intraocular pressure tracker. These features aim to increase patients' level of knowledge about glaucoma and improve their adherence to medication and follow-up appointment recommendations.

More Helpful (and Free) Apps from American Foundation for the Blind (AFB) and VisionAware

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Clinical Trial Update: Squalamine Eye Drops for Wet Macular Degeneration

Photograph of a retina with wet age-related macular degeneration

A retina with wet AMD

Many readers have been following closely the development of Squalamine Eye Drops for wet age-related macular degeneration, hoping that a self-administered at-home eye drop could reduce, or even eliminate, the need for monthly or as-needed eye injections. Unfortunately, a clinical trial designed to test this concept has produced disappointing results: Squalamine Eye Drops failed to reduce the average number of Lucentis injections required by the trial participants.

However, that clinical trial also revealed that squalamine produced positive changes in visual acuity – both overall in the Lucentis/squalamine treatment group, and, more significantly, in participants with a specific type of AMD lesion. As a result, a newer clinical trial, initiated in 2016 and continuing into 2019, will continue to study the effects of Squalamine Eye Drops, in combination with Lucentis injections, on gains in visual acuity in persons with wet macular degeneration.

What Is Squalamine?

Ohr Pharmaceutical, Inc. is dedicated to the clinical development of new drugs for underserved therapeutic needs. One of its lead drugs in development is Squalamine Eye Drops for the treatment of wet age-related macular degeneration (AMD).

Squalamine is a water-soluble molecule derived from the internal organs (primarily the liver) of the dogfish shark. It is believed to have great potential for treating some human viruses. Medically, squalamine has been shown to interrupt and reverse the process of angiogenesis.

About Angiogenesis and Anti-Angiogenic Drugs

Angiogenesis is a term that describes the growth of new blood vessels and plays a critical role in the normal development of body organs and tissue. Sometimes, however, excessive and abnormal blood vessel development can occur in diseases such as cancer (tumor growth) and AMD (retinal and macular bleeding).

Substances that stop the growth of these excessive blood vessels are called anti-angiogenic (anti=against; angio=vessel; genic=development), and anti-neovascular (anti=against; neo=new; vascular=blood vessels).

The focus of current anti-angiogenic drug treatments for wet macular degeneration is to reduce the level of a particular protein (vascular endothelial growth factor, or VEGF) that stimulates abnormal blood vessel growth in the retina and macula; thus, these drugs are classified as anti-VEGF treatments.

The squalamine researchers theorized that the ability to self-administer eye drops to treat wet AMD could be more effective (and less invasive) than the current standard of care, which involves regular injections of Lucentis, Avastin, or Eylea directly into the eye, via a very small needle. These injections are administered at the doctor's office.

A History of Squalamine Eye Drop Research

Initially, the Genaera Corporation developed the squalamine project and administered squalamine as an intravenous formulation for wet AMD in Phase 1 and Phase 2 clinical trials. However, in 2007, Genaera discontinued their clinical trials, due to financial and subject-recruitment issues. The squalamine project was then acquired by Ohr Pharmaceutical, which continued the development of squalamine in a topical eye drop formulation.

In 2012, Ohr was awarded "Fast Track" designation by the United States Food and Drug Administration (FDA) to further develop its Squalamine Eye Drop product for the potential treatment of wet AMD. Fast Track is a process designed to facilitate the development, and expedite the review, of drugs to treat serious diseases and fill an unmet medical need. Filling an unmet medical need is defined as providing a therapy where none exists or providing a therapy that may be potentially superior to existing therapy.

The Phase 2 Clinical Trial

In August 2012, the FDA commenced a Phase 2 clinical trial to study the safety and effectiveness of Squalamine Eye Drops in combination with Lucentis injections. The researchers were seeking to determine (a) if squalamine was safe (safety) and (b) if Squalamine Eye Drops could reduce the number and frequency of Lucentis injections required to control the neovascularization and retinal bleeding associated with wet AMD (effectiveness).

The initial enrollment in the clinical trial was 142 "treatment-naïve" participants [i.e., meaning that no participant had received prior treatments] at 23 clinical ophthalmology centers across the United States. 128 participants completed the study.

All participants in the nine-month study received an initial injection of Lucentis to begin and then were randomly assigned to receive either Squalamine Eye Drops [i.e., the treatment group] or placebo eye drops twice a day throughout the study. [Editor's note: A placebo is an inactive substance that has no therapeutic effect, used as a control in testing new drugs.]

All participants were seen monthly during the study period and received eye examinations, visual acuity testing, and optical coherence tomography (OCT) testing. Additional Lucentis injections were given on an as-needed basis to control the new blood vessel development and retinal bleeding associated with wet AMD. [Editor's note: Optical coherence tomography (OCT) is a type of medical imaging technology that produces high-resolution cross-sectional and three-dimensional images of the eye. It is used to gain a clearer picture of the retina and its supporting layers.]

You can learn more about the Phase 2 squalamine clinical trial, including criteria for enrollment and the locations of the clinical trial study centers, at Efficacy and Safety of Squalamine Eye Drops at

The Clinical Trial Results

Safety: Squalamine Eye Drops were well-tolerated. Only two participants in the treatment group discontinued the study, due to eye pain or swelling.

Effectiveness: Unfortunately, Squalamine Eye Drops failed to decrease the average number of Lucentis injections required by the study participants. This was the primary goal of the clinical trial and the result was disappointing, both to researchers and to people with wet AMD, who were hoping that Squalamine Eye Drops could possibly reduce, or even eliminate, the need for eye injections.

There Were Some Positive Results from the Phase 2 Clinical Trial

the ETDRS chart

The Early Treatment of Diabetic Retinopathy Study (ETDRS) Chart

Despite not reaching the study's primary end goal, there were additional results from the Phase 2 clinical trial that may be encouraging. Although Squalamine Eye Drops did not reduce the need for, or the frequency of, eye injections, squalamine did produce positive changes in visual acuity, or clearness of vision – both overall in the Lucentis/squalamine treatment group, and more significantly, in participants with a specific type of AMD lesion.

31% of the study participants who received the combined Lucentis/squalamine treatment gained 3 or more letters on the Early Treatment of Diabetic Retinopathy Study (ETDRS) Eye Chart (pictured at left), versus 25% of participants who received Lucentis treatment alone (meaning the Lucentis/placebo treatment).

However, 37 participants with "classic" AMD lesions who received the combined Lucentis/squalamine treatment gained 11 letters on the ETDRS Eye Chart, versus 5 letters with Lucentis treatment alone. Classic AMD lesions have also shown benefit in other studies of combined treatment.

A Phase 3 Clinical Trial Is Now Underway

Due to these gains in vision from the study's combination therapy, Ohr has moved forward with a Phase 3 clinical trial. The two-year trial, which commenced in 2016, will enroll 650 participants and is estimated to be completed in mid-2019. It will continue to study the effects of Squalamine Eye Drops in combination with Lucentis injections, versus Lucentis injections alone, on best-corrected visual acuity.

Update: On February 15, 2107, Ohr Pharmaceuticals announced that it had temporarily suspended new enrollment in the Phase 3 clinical trial. While the 200 patients currently enrolled in the study will continue to receive the therapy, the trial will be closed for new patients.

"This approach is intended to provide prospective efficacy data before year end 2017 to enable us to potentially confirm the visual acuity benefits observed in the patient population we identified as the most likely to benefit from Squalamine combination therapy. Given the recent study readouts from other combination therapy agents and the reaction to these results, we feel that a change in our clinical development program is warranted," said Dr. Jason Slakter, Chief Executive Officer of Ohr.

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